topologyGSA: Gene Set Analysis Exploiting Pathway Topology
Using Gaussian graphical models we propose a novel approach to
perform pathway analysis using gene expression. Given the
structure of a graph (a pathway) we introduce two statistical
tests to compare the mean and the concentration matrices between
two groups. Specifically, these tests can be performed on the
graph and on its connected components (cliques). The package is
based on the method described in Massa M.S., Chiogna M., Romualdi
C. (2010) <doi:10.1186/1752-0509-4-121>.
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